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Article

Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning.

Developmental biology - 15 May 1998

Capdevila J, Johnson R L

Abstract excerpt

The gene noggin, originally cloned in Xenopus, encodes a secreted factor expressed in the Spemann organizer, where it functions to oppose the ventralizing influence of bone morphogenetic proteins (BMPs). Noggin protein acts by binding directly to BMPs, thereby preventing them from interacting wit...

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PMID: 9630747
DOI: 10.1006/dbio.1997.8824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9630747-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning.PMID 9630747Read ↗

Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.Semantic proximity Read ↗

The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defectsSemantic proximity Read ↗

Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis.Semantic proximity Read ↗

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.Semantic proximity Read ↗

Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN.Semantic proximity Read ↗

The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.Semantic proximity Read ↗

Patterning the zebrafish axial skeleton requires early chordin function.Semantic proximity Read ↗

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis.Semantic proximity Read ↗

Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis.Semantic proximity Read ↗

Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge.Semantic proximity Read ↗

Bone Morphogenetic Protein Signals Are Required for Cartilage Formation and Differently Regulate Joint Development During SkeletogenesisSemantic proximity Read ↗

The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.Semantic proximity Read ↗

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