Article
Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.
Mechanisms of development - 1 Dec 1997
Suda Y, Matsuo I, Aizawa S
Abstract excerpt
Otx1 and Otx2 genes are mouse cognates of a Drosophila head gap gene orthodenticle. The homozygous mutants have previously indicated that Otx2 is essential to development of structures anterior to rhombomere 3, probably reflecting its expression around the early primitive streak stage. Otx2 mutat...
Topics
- Animals
- Brain
- Crosses, Genetic
- Diencephalon
- Female
- Fibroblast Growth Factor 8
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Growth Substances
- Homeodomain Proteins
- Mesencephalon
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Mutant Strains
- Nerve Tissue Proteins
- Otx Transcription Factors
- Phenotype