Article
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.
Development (Cambridge, England) - 1 Mar 2001
Perea-Gomez A, Lawson K A, Rhinn M, Zakin L, Brûlet P, Mazan S, Ang S L
Abstract excerpt
Genetic and embryological experiments have demonstrated an essential role for the visceral endoderm in the formation of the forebrain; however, the precise molecular and cellular mechanisms of this requirement are poorly understood. We have performed lineage tracing in combination with molecular marker studies to follow morphogenetic movements and cell fates before and during gastrulation in embryos mutant for...
Topics
- Animals
- Biomarkers
- Body Patterning
- Cell Lineage
- Cell Movement
- Clone Cells
- DNA
- Ectoderm
- Embryonic and Fetal Development
- Endoderm
- Gastrula
- Genotype
- Homeodomain Proteins
- Horseradish Peroxidase