Article
Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.
Development (Cambridge, England) - 1 Jul 2004
Kurokawa Daisuke, Takasaki Nobuyoshi, Kiyonari Hiroshi, Nakayama Rika, Kimura-Yoshida Chiharu, Matsuo Isao, Aizawa Shinichi
Abstract excerpt
We have identified cis-regulatory sequences acting on Otx2 expression in epiblast (EP) and anterior neuroectoderm (AN) at about 90 kb 5' upstream. The activity of the EP enhancer is found in the inner cell mass at E3.5 and the entire epiblast at E5.5. The AN enhancer activity is detected initially at E7.0 and ceases by E8.5; it is found later in the dorsomedial aspect of the telencephalon at E10.5. The EP...
Topics
- Alleles
- Animals
- Base Sequence
- Body Patterning
- Brain
- Chromosomes, Artificial, Bacterial
- Ectoderm
- Enhancer Elements, Genetic
- Gene Deletion
- Gene Expression Regulation, Developmental
- Genotype
- Homeodomain Proteins
- In Situ Hybridization