Article
Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
Development (Cambridge, England) - 1 Oct 1995
Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brûlet P
Abstract excerpt
We have replaced part of the mouse homeogene Otx2 coding region with the E. coli lacZ coding sequence, thus creating a null allele of Otx2. By 9.5 dpc, homozygous mutant embryos are characterized by the absence of forebrain and midbrain regions. From the early to midstreak stages, endomesodermal...
Topics
- Animals
- Base Sequence
- Brain
- DNA Primers
- Ectoderm
- Embryonic Induction
- Gastrula
- Genes, Homeobox
- Homeodomain Proteins
- In Situ Hybridization
- Lac Operon
- Mesencephalon
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Nerve Tissue Proteins
- Otx Transcription Factors