Article
OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.
Gene expression patterns : GEP - 1 Aug 2003
Acampora Dario, Annino Alessandro, Puelles Eduardo, Alfano Ivan, Tuorto Francesca, Simeone Antonio
Abstract excerpt
Otx genes play a relevant role in specification, maintenance and patterning of anterior neuroectoderm. OTX1 and OTX2 proteins share extensive codogenic similarity even though in OTX1 these regions of homology are separated by stretches of amino acid insertions. From 1 to 3 somites stage onwards, Otx1 and Otx2 are largely coexpressed, but only Otx2 is expressed during gastrulation. To determine whether OTX1 and...
Topics
- Animals
- Body Patterning
- DNA-Binding Proteins
- Ectoderm
- Female
- Fibroblast Growth Factor 8
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Humans
- In Situ Hybridization
- Male
- Mesencephalon