Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.

Gene expression patterns : GEP - 1 Aug 2003

Acampora Dario, Annino Alessandro, Puelles Eduardo, Alfano Ivan, Tuorto Francesca, Simeone Antonio

Abstract excerpt

Otx genes play a relevant role in specification, maintenance and patterning of anterior neuroectoderm. OTX1 and OTX2 proteins share extensive codogenic similarity even though in OTX1 these regions of homology are separated by stretches of amino acid insertions. From 1 to 3 somites stage onwards, Otx1 and Otx2 are largely coexpressed, but only Otx2 is expressed during gastrulation. To determine whether OTX1 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Ectoderm
Share to Fibroblast Growth Factor 8

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblast Growth Factors

Share to Mesencephalon

Share to Otx Transcription Factors

Share to PAX2 Transcription Factor

Share to Prosencephalon

Source

Identifiers

PMID: 12915318
DOI: 10.1016/s1567-133x(03)00056-5

Genes

OTX1
OTX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.PMID 12915318Read ↗

Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.Semantic proximity Read ↗

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.Semantic proximity Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.Semantic proximity Read ↗

Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain.Semantic proximity Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation.Semantic proximity Read ↗

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.Semantic proximity Read ↗

Mouse Otx2 functions in the formation and patterning of rostral head.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.