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Article

Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Nov 1996

Suda Y, Matsuo I, Kuratani S, Aizawa S

Abstract excerpt

BACKGROUND: We previously reported that the homozygous mutation of Otx2 gene, a mouse cognate of the Drosophila head gap gene orthodenticle, causes failure in the development of the rostral head anterior to rhombomere 3, which may correspond to earlier Otx2 expression in cells destined for the anterior mesoendoderm. At the same time, the Otx2 heterozygous mutation displayed a phenotype characterized as...

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Identifiers

PMID: 9077465
DOI: 10.1046/j.1365-2443.1996.900288.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain.PMID 9077465Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Mouse Otx2 functions in the formation and patterning of rostral head.Semantic proximity Read ↗

Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.Semantic proximity Read ↗

Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.Semantic proximity Read ↗

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.Semantic proximity Read ↗

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

Otx genes in the development and evolution of the vertebrate brain.Semantic proximity Read ↗

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.Semantic proximity Read ↗

The role of Otx and Otp genes in brain development.Semantic proximity Read ↗

Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.Semantic proximity Read ↗

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