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Article

Defective transforming growth factor beta signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2001

Muro-Cacho C A, Rosario-Ortiz K, Livingston S, Muñoz-Antonia T

Abstract excerpt

PURPOSE: Transforming growth factor beta (TGF-beta) regulates cell growth and differentiation, in normal squamous epithelium, via specific TGF-beta receptors and intracellular signaling molecules (Smads). We have previously observed that TGF-beta type II receptor (TbetaR-II) expression decreases in squamous cell carcinomas as tumors become less differentiated and more biologically aggressive. However, a small...

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Share to Carcinoma, Squamous Cell
Share to Epithelium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Image Processing, Computer-Assisted

Share to Receptors, Transforming Growth Factor beta

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Source

Identifiers

PMID: 11410498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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