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Article

A novel dominant negative Smad2 mutation in a TGFbeta resistant human carcinoma cell line.

Anticancer research - 1 Jan 2000

Tsang Kenneth J, Tsang David, Brown Tamara N, Crowe David L

Abstract excerpt

An important biological mechanism contributing to the transformed phenotype of cancer cells is the ability to escape normal growth regulatory signals. In epithelial cells, transforming growth factor beta (TGFbeta) inhibits cell cycle progression in the G1-phase. The abnormal ability of cancer cells to escape TGFbeta-induced cell cycle inhibition may lead to deregulated mitosis, providing a growth advantage to...

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Share to Carcinoma, Squamous Cell
Share to Drug Resistance, Neoplasm
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Transforming Growth Factor beta

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Share to Trans-Activators

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Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12017275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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