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Article

Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.

Genes & development - 15 May 2006

Lu Shi-Long, Herrington Heather, Reh Douglas, Weber Stephen, Bornstein Sophia, Wang Donna, Li Allen G, Tang Chin-Fang, Siddiqui Yasmin, Nord Jo, Andersen Peter, Corless Christopher L, Wang Xiao-Jing

Abstract excerpt

The prognosis of head-and-neck squamous cell carcinoma (HNSCC) has not been improved in the past 20 years. Validation of HNSCC biomarkers for targeted therapy has been hindered by a lack of animal models mimicking human HNSCC at both the pathological and molecular levels. Here we report that overexpression of K-ras or H-ras and loss of transforming growth factor-beta type II receptor (TGFbetaRII) are common...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

Share to Proto-Oncogene Proteins p21(ras)

Share to Receptor, Transforming Growth Factor-beta Type II

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Source

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Identifiers

PMID: 16702406
DOI: 10.1101/gad.1413306
PMCID: PMC1472907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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