Article
Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck.
Carcinogenesis - 1 Nov 1997
Wang D, Song H, Evans J A, Lang J C, Schuller D E, Weghorst C M
Abstract excerpt
In the present study, we analyzed 28 squamous cell carcinomas of the head and neck (SCCHN) for mutations in the coding region of TbetaR-II using 'Cold' SSCP and automatic DNA sequencing analyses. Twenty-one percent (6/28) of the SCCHN examined contained TbetaR-II mutations compared with patient-m...
Topics
- Carcinoma, Squamous Cell
- Down-Regulation
- Gene Expression Regulation, Neoplastic
- Head and Neck Neoplasms
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- RNA, Messenger
- Receptors, Transforming Growth Factor beta