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Article

Partial loss of Smad signaling during in vitroprogression of HPV16-immortalized human keratinocytes

18 Sept 2013

Abstract excerpt

BACKGROUND: Disruption of the transforming growth factor-beta (TGF-β) signaling pathway is observed in many cancers, including cervical cancer, resulting in TGF-β resistance. While normal human keratinocytes (HKc) and human papillomavirus type 16-immortalized HKc (HKc/HPV16) are sensitive to the growth inhibitory effects of TGF-β, HKc/HPV16 develop resistance to TGF-β1 as they progress in vitro to a...

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PMID: 24047375
DOI: 10.1186/1471-2407-13-424

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