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Article

Mechanism for mutational inactivation of the tumor suppressor Smad2.

Molecular and cellular biology - 1 May 2001

Prunier C, Ferrand N, Frottier B, Pessah M, Atfi A

Abstract excerpt

Transforming growth factor beta (TGF-beta) is a potent natural antiproliferative agent that plays an important role in suppressing tumorigenicity. In numerous tumors, loss of TGF-beta responsiveness is associated with inactivating mutations that can occur in components of this signaling pathway, such as the tumor suppressor Smad2. Although a general framework for how Smads transduce TGF-beta signals has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11313456
DOI: 10.1128/MCB.21.10.3302-3313.2001
PMCID: PMC100252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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