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Article

Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder.

Mutation research - 1 Jun 2001

Kimura F, Florl A R, Steinhoff C, Golka K, Willers R, Seifert H H, Schulz W A

Abstract excerpt

Because polymorphisms in the methyl group metabolism genes methylene-tetrahydrofolate reductase (MTHFR), methionine synthase (MS), and cystathione beta-synthetase (CBS) affect plasma homocysteine levels and intracellular concentrations of S-adenosylmethionine (SAM), they modify the susceptibility to cardiovascular diseases and cancer. Specifically, genome-wide decreased DNA methylation ('hypomethylation') in...

Read the complete abstract on PubMed

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Transitional Cell

Share to Cystathionine beta-Synthase

Share to DNA, Neoplasm

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 11406421
DOI: 10.1016/s1383-5726(01)00010-3

Genes

CBS
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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