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Article

Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors.

Bulletin du cancer - 1 Feb 2011

Rouissi Kamel, Stambouli Najla, Marrakchi Raja, Slama Mohamed R Ben, Cherif Mohamed, Sfaxi Mohamed, Chebil Mohamed, Elgaaied Amel Benammar, Ouerhani Slah

Abstract excerpt

Folates are the common sources of DNA synthesis and methylation. Cigarette smoking and genetic susceptibility of folate enzymes are two suspected factors most closely associated with bladder cancer development. This study sought to determine the effect of smoking and genetic polymorphisms in folate metabolizing enzymes on the histological stage and grade of bladder tumors in Tunisian patients. A total of 130...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Carcinoma, Transitional Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Smoking

Share to Thymidylate Synthase

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 21339095
DOI: 10.1684/bdc.2011.1312

Genes

TYMS
MTHFR
MTR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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