Article
Methylenetetrahydrofolate reductase and methionine synthase polymorphisms and risk of bladder cancer in a Tunisian population.
Cancer genetics and cytogenetics - 1 Jul 2007
Ouerhani Slah, Oliveira Elisabete, Marrakchi Raja, Ben Slama Mohamed R, Sfaxi Mohamed, Ayed Mohsen, Chebil Mohamed, Amorim António, El Gaaied Amel Benammar, Prata Maria João
Abstract excerpt
Folate insufficiency can induce carcinogenesis by decreasing DNA methylation. It is well known that DNA hypomethylation is a common feature in a number of cancers. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are enzymes that play central roles in the folate metabolic pathway. Two common polymorphisms in the MTHFR gene (C677T and A1298C) and one in the MS gene (A2756G) are associated...
Topics
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- Aged
- Case-Control Studies
- Cohort Studies
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Odds Ratio
- Polymorphism, Genetic