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Article

Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis.

Clinical and experimental medicine - 1 Mar 2009

Wang Meilin, Zhu Haixia, Fu Guangbo, Wang Miaomiao, Zhang Zhizhong, Lu Qiang, Wang Shizhi, Zhang Zhengdong

Abstract excerpt

Folate deficiency due to the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) variants leads to carcinogenesis by affecting DNA synthesis, repair, and methylation. We hypothesized that the MTHFR C677T, A1298C, and MS A2756G polymorphisms are associated with risk of bladder cancer. In a case-control study of 239 bladder cancer cases and 250 cancer-free controls, we found that the MTHFR...

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Identifiers

PMID: 18815869
DOI: 10.1007/s10238-008-0013-1

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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