Article
Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma.
The Prostate - 1 Nov 2000
Kimura F, Franke K H, Steinhoff C, Golka K, Roemer H C, Anastasiadis A G, Schulz W A
Abstract excerpt
BACKGROUND: Alterations of DNA methylation are very frequent in prostatic carcinoma. A possible cause underlying altered DNA methylation could be an insufficient level of S-adenosylmethionine as a consequence of nutritional imbalances or of weaker alleles of genes for its synthesis, i.e., encoding methylene-tetrahydrofolate reductase (MTHFR), methionine synthase (MS), and beta-cystathione synthetase (CBS)....
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