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Article

Genetic polymorphisms of MTHFR and aberrant promoter hypermethylation of the RASSF1A gene in bladder cancer risk in a Chinese population.

The Journal of international medical research - 1 Jan 2000

Cai D W, Liu X F, Bu R G, Chen X N, Ning L, Cheng Y, Wu B

Abstract excerpt

Epidemiological studies have shown that folate deficiency increases the risk of cancer by affecting DNA repair and methylation. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. In this study, it was hypothesized that MTHFR (C677T and A1298C) polymorphisms would be associated with bladder cancer and also with hypermethylation of the promoter of the Ras association domain family 1A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Tumor Suppressor Proteins

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 20146887
DOI: 10.1177/147323000903700625

Genes

MTHFR

Variants

Provenance

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