Article
Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population.
Cancer genetics and cytogenetics - 1 Nov 2009
Rouissi Kamel, Ouerhani Slah, Oliveira Elisabete, Marrakchi Raja, Cherni Lotfi, Ben Othman Fethi, Ben Slama Mohamed R, Sfaxi Mohamed, Ayed Mohsen, Chebil Mohamed, Amorim António, Prata Maria João, Benammar Elgaaied Amel
Abstract excerpt
Cigarette smoking is the most important risk factor for bladder cancer. Moreover, epidemiologic studies have implicated several genetic variations interfering with methyl group metabolisms in susceptibility for a variety of cancers. Examples of these variations can be found in genes of the folate metabolic pathway, which is crucial in the provision of methyl groups for DNA, RNA, and protein methylation, as well...
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