Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2001

Shefi-Friedman L, Wertheimer E, Shen S, Bak A, Accili D, Sampson S R

Abstract excerpt

We have studied the role of the insulin receptor (IR) in metabolic and growth-promoting effects of insulin on primary cultures of skeletal muscle derived from the limb muscle of IR null mice. Cultures of IR null skeletal muscle displayed normal morphology and spontaneous contractile activity. Expression of muscle-differentiating proteins was slightly reduced in myoblasts and myotubes of the IR null skeletal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport, Active
Share to Cell Fractionation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Insulin-Like Growth Factor I

Share to Precipitin Tests

Share to Receptor, IGF Type 1

Share to Receptor, IGF Type 2

Share to Receptor, Insulin

Source

Identifiers

PMID: 11404219
DOI: 10.1152/ajpendo.2001.281.1.E16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice.PMID 11404219Read ↗

Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice.Semantic proximity Read ↗

Mosaic analysis of insulin receptor function.Semantic proximity Read ↗

Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.Semantic proximity Read ↗

The role of insulin receptor signaling in zebrafish embryogenesis.Semantic proximity Read ↗

Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant.Semantic proximity Read ↗

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.Semantic proximity Read ↗

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance.Semantic proximity Read ↗

Endocrine pancreas in insulin receptor-deficient mouse pups.Semantic proximity Read ↗

AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.Semantic proximity Read ↗

Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.Semantic proximity Read ↗

In vivo metabolic effects of insulin-like growth factor-I not mediated through the insulin receptor.Semantic proximity Read ↗

Insulin-like growth factor I (IGF-I) receptor overexpression abolishes the IGF requirement for differentiation and induces a ligand-dependent transformed phenotype in C2 inducible myoblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.