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Article

Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.

The Journal of biological chemistry - 15 Apr 2005

Sadagurski Marianna, Weingarten Galina, Rhodes Christopher J, White Morris F, Wertheimer Efrat

Abstract excerpt

The insulin receptor substrate 2 (IRS-2) protein is one of the major insulin-signaling substrates. In the present study, we investigated the role of IRS-2 in skin epidermal keratinocytes and dermal fibroblasts. Although skin is not a classical insulin target tissue, we have previously demonstrated that insulin, via the insulin receptor, is essential for normal skin cell physiology. To identify the role of IRS-2...

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Identifiers

PMID: 15705592
DOI: 10.1074/jbc.M410227200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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