The role of insulin receptor signaling in zebrafish embryogenesis.

doi:10.1210/en.2008-0329

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Article

The role of insulin receptor signaling in zebrafish embryogenesis.

Endocrinology - 1 Dec 2008

Toyoshima Yuka, Monson Christopher, Duan Cunming, Wu Yingjie, Gao Chuan, Yakar Shoshana, Sadler Kirsten C, LeRoith Derek

Abstract excerpt

Insulin receptor (IR) signaling is considered to be important in growth and development in addition to its major role in metabolic homeostasis. The metabolic role of insulin in carbohydrate and lipid metabolism is extensively studied. In contrast, the role of IR activation during embryogenesis is less understood. To address this, we examined the function of the IR during zebrafish development. Zebrafish express...

Topics

Animals
Blotting, Western
Cell Line
Gene Expression Regulation, Developmental
In Situ Hybridization
Mice
Mutation
Protein Isoforms
Receptor, Insulin
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Zebrafish

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Identifiers

PMID: 18687786
DOI: 10.1210/en.2008-0329
PMCID: PMC2613066

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