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Article

Endocrine pancreas in insulin receptor-deficient mouse pups.

Diabetes - 1 Feb 2001

Jackerott M, Baudry A, Lamothe B, Bucchini D, Jami J, Joshi R L

Abstract excerpt

Insulin receptor (IR)-deficient pups rapidly become hyperglycemic and hyperinsulinemic and die of diabetic ketoacidosis within a few days. Immunocytochemical analysis of the endocrine pancreas revealed that IR deficiency did not alter islet morphology or the number of beta-, alpha-, delta-, and pancreatic polypeptide (PP) cells. The lack of IR did not result in major changes in the expression of islet hormone...

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Source

Identifiers

PMID: 11272177
DOI: 10.2337/diabetes.50.2007.s146

Genes

GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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