Article
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.
The Journal of biological chemistry - 20 Oct 2006
Kramer Henning F, Witczak Carol A, Taylor Eric B, Fujii Nobuharu, Hirshman Michael F, Goodyear Laurie J
Abstract excerpt
Insulin and contraction are potent stimulators of GLUT4 translocation and increase skeletal muscle glucose uptake. We recently identified the Rab GTPase-activating protein (GAP) AS160 as a putative point of convergence linking distinct upstream signaling cascades induced by insulin and contraction in mouse skeletal muscle. Here, we studied the functional implications of these AS160 signaling events by using an in...
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