Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mosaic analysis of insulin receptor function.

The Journal of clinical investigation - 1 Jan 2004

Kitamura Tadahiro, Kitamura Yukari, Nakae Jun, Giordano Antonio, Cinti Saverio, Kahn C Ronald, Efstratiadis Argiris, Accili Domenico

Abstract excerpt

Insulin promotes both metabolism and growth. However, it is unclear whether insulin-dependent growth is merely a result of its metabolic actions. Targeted ablation of insulin receptor (Insr) has not clarified this issue, because of early postnatal lethality. To examine this question, we generated mice with variable cellular mosaicism for null Insr alleles. Insr ablation in approximately 80% of cells caused...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Receptor, Insulin
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blotting, Northern

Share to Hyperplasia

Share to Hypoglycemia

Share to Insulin-Like Growth Factor Binding Protein 1

Share to Microscopy, Electron

Share to Mosaicism

Source

Open in PubMed Open full text

Identifiers

PMID: 14722613
DOI: 10.1172/JCI17810
PMCID: PMC310748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mosaic analysis of insulin receptor function.PMID 14722613Read ↗

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.Semantic proximity Read ↗

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose ToleranceSemantic proximity Read ↗

Gene expression in human cells with mutant insulin receptors.Semantic proximity Read ↗

Tissue-specific inactivation of murine M6P/IGF2R.Semantic proximity Read ↗

Distinct and overlapping functions of insulin and IGF-I receptors.Semantic proximity Read ↗

Tissue-Specific GHR Knockout Mice: Metabolic PhenotypesSemantic proximity Read ↗

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.Semantic proximity Read ↗

Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS CellsSemantic proximity Read ↗

Knockout Mice Challenge our Concepts of Glucose Homeostasis and the Pathogenesis of DiabetesSemantic proximity Read ↗

Mutant insulin receptors in syndromes of insulin resistance.Semantic proximity Read ↗

Molecular defects of insulin/IGF-1 receptor transmembrane signaling.Semantic proximity Read ↗

Knockout mouse models of insulin signaling: Relevance past and futureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.