Article
Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant.
The Journal of biological chemistry - 15 Jun 1991
Moller D E, Benecke H, Flier J S
Abstract excerpt
We have studied insulin receptor-mediated signaling in Chinese hamster ovary (CHO) cell transfectants that expressed either of two naturally occurring mutant human insulin receptors: Trp1200----Ser1200 and Ala1134----Thr1134. Compared with overexpressed normal human insulin receptors, both mutant...
Topics
- Animals
- Cell Line
- DNA Replication
- Gene Expression
- Glucose
- Glycogen
- Humans
- Insulin
- Kinetics
- Monosaccharide Transport Proteins
- Mutation
- Protein-Tyrosine Kinases
- Receptor, Insulin
- Transfection