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Article

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.

Experimental gerontology - 1 Jan 2000

Masternak Michal M, Al-Regaiey Khalid A, Del Rosario Lim Marc Michael, Jimenez-Ortega Vanesa, Panici Jacob A, Bonkowski Michael S, Bartke Andrzej

Abstract excerpt

Growth hormone receptor/binding protein knockout (GHR-KO) mice are characterized by resistance to growth hormone (GH), reduced insulin like growth factor 1 (IGF1) levels and enhanced insulin sensitivity and markedly increased lifespan. Findings in these and other long-lived mutant mice, and in normal animals subjected to caloric restriction (CR) indicate that insulin signaling is importantly involved in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin Receptor Substrate Proteins

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Share to Receptor, IGF Type 1

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Source

Identifiers

PMID: 16054319
DOI: 10.1016/j.exger.2005.06.003

Genes

GHR
IGF1
IRS1
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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