Article
Anionic phospholipids are involved in membrane targeting of PI 3-kinase gamma.
Biochemical and biophysical research communications - 6 Apr 2001
Kirsch C, Wetzker R, Klinger R
Abstract excerpt
Phosphoinositide 3-kinases (PI 3-kinases) have critical roles in diverse cellular signaling processes and in protein trafficking. In contrast to the class I PI 3-kinases alpha, beta, and delta which bind via src homology 2 (SH2) domains of adaptor proteins to tyrosine kinase receptors, the mechanism of recruitment of the PI 3-kinase gamma to membranes is unknown. We report in vitro experiments using immobilized...
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