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Article

Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma.

The Journal of biological chemistry - 11 Feb 2005

Voigt Philipp, Brock Carsten, Nürnberg Bernd, Schaefer Michael

Abstract excerpt

Phosphoinositide 3-Kinase (PI3K) gamma is a lipid kinase that is regulated by G-protein-coupled receptors. It plays a crucial role in inflammatory and allergic processes. Activation of PI3Kgamma is primarily mediated by Gbetagamma subunits. The regulatory p101 subunit of PI3Kgamma binds to Gbetagamma and, thereby, recruits the catalytic p110gamma subunit to the plasma membrane. Despite its crucial role in the...

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PMID: 15611065
DOI: 10.1074/jbc.M413104200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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