Article
Phosphatidylinositol 4,5-bisphosphate anchors cytosolic group IVA phospholipase A2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells.
Molecular biology of the cell - 1 Jan 2006
Casas Javier, Gijón Miguel A, Vigo Ana G, Crespo Mariano Sánchez, Balsinde Jesús, Balboa María A
Abstract excerpt
The eicosanoids are centrally involved in the onset and resolution of inflammatory processes. A key enzyme in eicosanoid biosynthesis during inflammation is group IVA phospholipase A2 (also known as cytosolic phospholipase A2alpha, cPLA2alpha). This enzyme is responsible for generating free arach...
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