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Article

Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2011

Lee Jennifer Y, Chiu Yu-Hsin, Asara John, Cantley Lewis C

Abstract excerpt

Class IA PI3Ks are activated by growth factor receptors and generate lipid second messengers that mediate downstream responses including cell growth, cell migration, and cell survival. The p85 regulatory subunit of PI3K contains Src homology-2 (SH2) domains that mediate binding to tyrosine-phosphorylated receptors or adaptor proteins to facilitate localization and activation of PI3K at the plasma membrane. We...

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Source

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Identifiers

PMID: 21825134
DOI: 10.1073/pnas.1107747108
PMCID: PMC3161555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.PMID 21825134Read ↗

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