Article

Anionic lipids regulate PLCβ membrane recruitment

2026-07-21

Abstract excerpt

Phospholipase C-β (PLCβ) enzymes are essential effectors of G protein-coupled receptor signaling that hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) at the plasma membrane to generate the second messengers inositol trisphosphate and diacylglycerol. PLCβs play essential roles in diverse physiological processes, including cardiac and neuronal function, macrophage activation, and the pathogenesis of diseases...

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Literature Corpus work: a1d83d9d-622a-59b0-a8a8-39f0bde4ee37
DOI: 10.64898/2026.07.20.739664

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