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Article

Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms.

The Journal of biological chemistry - 12 Nov 2010

Ghomashchi Farideh, Naika Gajendra S, Bollinger James G, Aloulou Ahmed, Lehr Matthias, Leslie Christina C, Gelb Michael H

Abstract excerpt

The cytosolic (group IV) phospholipase A(2) (cPLA(2)s) family contains six members. We have prepared recombinant proteins for human α, mouse β, human γ, human δ, human ε, and mouse ζ cPLA(2)s and have studied their interfacial kinetic and binding properties in vitro. Mouse cPLA(2)β action on phosphatidylcholine vesicles is activated by anionic phosphoinositides and cardiolipin but displays a requirement for...

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Identifiers

PMID: 20705608
DOI: 10.1074/jbc.M110.165647
PMCID: PMC2975232

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