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Article

Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.

The Journal of biological chemistry - 12 Nov 2010

Gresset Aurelie, Hicks Stephanie N, Harden T Kendall, Sondek John

Abstract excerpt

The lipase activity of most phospholipases C (PLCs) is basally repressed by a highly degenerate and mostly disordered X/Y linker inserted within the catalytic domain. Release of this auto-inhibition is driven by electrostatic repulsion between the plasma membrane and the electronegative X/Y linker. In contrast, PLC-γ isozymes (PLC-γ1 and -γ2) are structurally distinct from other PLCs because multiple domains are...

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Identifiers

PMID: 20807769
DOI: 10.1074/jbc.M110.166512
PMCID: PMC2975207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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