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Article

Protein kinase C activation by acidic proteins including 14-3-3.

The Biochemical journal - 1 May 2000

Van Der Hoeven P C, Van Der Wal J C, Ruurs P, Van Blitterswijk W J

Abstract excerpt

14-3-3 proteins may function as adapter or scaffold proteins in signal transduction pathways. We reported previously that several 14-3-3 isotypes bind to protein kinase C (PKC)-zeta and facilitate coupling of PKC-zeta to Raf-1 [van der Hoeven, van der Wal, Ruurs, van Dijk and van Blitterswijk (2000) Biochem. J. 345, 297-306], an event that boosts the mitogen-activated protein kinase (ERK) pathway in Rat-1...

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Identifiers

PMID: 10769183
DOI: 10.1042/0264-6021:3470781
PMCID: PMC1221016

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