Article
Characterization of Escherichia coli type 1 pilus mutants with altered binding specificities.
Journal of bacteriology - 1 Jul 2001
Harris S L, Spears P A, Havell E A, Hamrick T S, Horton J R, Orndorff P E
Abstract excerpt
PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli type 1 pili. These mutants were noteworthy in part because both were altered in the normal range of cell types bound by FimH. One mutation altered an amino acid at a site previously shown to be involved in...
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