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Article

Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection.

Molecular microbiology - 1 May 2002

Hung Chia-Suei, Bouckaert Julie, Hung Danielle, Pinkner Jerome, Widberg Charlotte, DeFusco Anthony, Auguste C Gale, Strouse Robert, Langermann Solomon, Waksman Gabriel, Hultgren Scott J

Abstract excerpt

The first step in the colonization of the human urinary tract by pathogenic Escherichia coli is the mannose-sensitive binding of FimH, the adhesin present at the tip of type 1 pili, to the bladder epithelium. We elucidated crystallographically the interactions of FimH with D-mannose. The unique site binding pocket occupied by D-mannose was probed using site-directed mutagenesis. All but one of the mutants...

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Source

Identifiers

PMID: 12010488
DOI: 10.1046/j.1365-2958.2002.02915.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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