Article
Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2009
Chen Swaine L, Hung Chia S, Pinkner Jerome S, Walker Jennifer N, Cusumano Corinne K, Li Zhaoli, Bouckaert Julie, Gordon Jeffrey I, Hultgren Scott J
Abstract excerpt
FimH, the type 1 pilus adhesin of uropathogenic Escherichia coli (UPEC), contains a receptor-binding domain with an acidic binding pocket specific for mannose. The fim operon, and thus type 1 pilus production, is under transcriptional control via phase variation of an invertible promoter element. FimH is critical during urinary tract infection for mediating colonization and invasion of the bladder epithelium and...
Topics
- Adhesins, Escherichia coli
- Amino Acid Substitution
- Animals
- Escherichia coli Infections
- Fimbriae Proteins
- Genes, Bacterial
- Mannose
- Mice
- Mice, Inbred C3H
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed