Article
Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation.
Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2013
Schwartz Drew J, Kalas Vasilios, Pinkner Jerome S, Chen Swaine L, Spaulding Caitlin N, Dodson Karen W, Hultgren Scott J
Abstract excerpt
Chaperone-usher pathway pili are a widespread family of extracellular, Gram-negative bacterial fibers with important roles in bacterial pathogenesis. Type 1 pili are important virulence factors in uropathogenic Escherichia coli (UPEC), which cause the majority of urinary tract infections (UTI). FimH, the type 1 adhesin, binds mannosylated glycoproteins on the surface of human and murine bladder cells,...
Topics
- Adhesins, Escherichia coli
- Alleles
- Amino Acid Sequence
- Amino Acids
- Animals
- Chronic Disease
- Coinfection
- Cystitis
- Escherichia coli
- Fimbriae Proteins
- Humans
- Mannose
- Mice