Valency conversion in the type 1 fimbrial adhesin of Escherichia coli.

doi:10.1046/j.1365-2958.2001.02545.x

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Article

Valency conversion in the type 1 fimbrial adhesin of Escherichia coli.

Molecular microbiology - 1 Aug 2001

Sokurenko E V, Schembri M A, Trintchina E, Kjaergaard K, Hasty D L, Klemm P

Abstract excerpt

FimH protein is a lectin-like adhesive subunit of type 1, or mannose-sensitive, fimbriae that are found on the surface of most Escherichia coli strains. All naturally occurring FimH variants demonstrate a conserved mannotriose-specific (i.e. multivalent) binding. Here, we demonstrate that replacement of residues 185-279 within the FimH pilin domain with a corresponding segment of the type 1C fimbrial adhesin FocH...

Topics

Adhesins, Bacterial
Adhesins, Escherichia coli
Agglutination
Amino Acid Sequence
Animals
Bacterial Adhesion
Cattle
Cells, Cultured
Cricetinae
Erythrocytes
Escherichia coli
Fimbriae Proteins
Lectins, C-Type
Mannose Receptor

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Mannose-Binding Lectins

Methylmannosides

Molecular Sequence Data

Phenotype

Source

Open in PubMed

Identifiers

PMID: 11532135
DOI: 10.1046/j.1365-2958.2001.02545.x

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