Article
Bone strength and related traits in HcB/Dem recombinant congenic mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2001
Yershov Y, Baldini T H, Villagomez S, Young T, Martin M L, Bockman R S, Peterson M G, Blank R D
Abstract excerpt
Fracture susceptibility depends jointly on bone mineral content (BMC), gross bone anatomy, and bone microarchitecture and quality. Overall, it has been estimated that 50-70% of bone strength is determined genetically. Because of the difficulty of performing studies of the genetics of bone strength in humans, we have used the HcB/Dem series of recombinant congenic (RC) mice to investigate this phenotype. We...
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