Article
Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2004
Volkman Suzanne K, Galecki Andrzej T, Burke David T, Miller Richard A, Goldstein Steven A
Abstract excerpt
UNLABELLED: The goal of this study was to investigate genetic effects on mechanical properties of the mouse femur. We found evidence for QTL on eight chromosomes that affect mechanical traits. Some of these QTL may have primary effects on body weight or femoral geometry, and others seem to affect bone quality directly. INTRODUCTION: Previous studies have shown a dependence of fragility-related fracture risk on...
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