Article
Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2001
Klein O F, Carlos A S, Vartanian K A, Chambers V K, Turner E J, Phillips T J, Belknap J K, Orwoll E S
Abstract excerpt
Bone mineral density (BMD) is determined by both environmental influences and polygenic inheritance. The extreme difficulty of dissecting out environmental factors from genetic ones in humans has motivated the investigation of animal models. Previously, we used quantitative trait locus (QTL) analysis to examine peak BMD in 24 recombinant inbred (RI) mouse strains, derived from a cross between C57BL/6 (B6) and...
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