Article
Linkage mapping of femoral material properties in a reciprocal intercross of HcB-8 and HcB-23 recombinant mouse strains.
Bone - 1 May 2010
Saless Neema, Lopez Franco Gloria E, Litscher Suzanne, Kattappuram Robbie S, Houlihan Meghan J, Vanderby Ray, Demant Peter, Blank Robert D
Abstract excerpt
Skeletal fragility is an important health problem with a large genetic component. We performed a 603 animal F2 reciprocal intercross of the recombinant congenic strains HcB-8 and HcB-23 to genetically map quantitative trait loci (QTLs) for tissue-level femoral biomechanical performance. These included elastic and post-yield strain, Young's modulus, elastic and maximum stress, and toughness and were calculated...
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