Article
Quantitative trait loci for biomechanical performance and femoral geometry in an intercross of recombinant congenic mice: restriction of the Bmd7 candidate interval.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2009
Saless Neema, Litscher Suzanne J, Lopez Franco Gloria E, Houlihan Meghan J, Sudhakaran Shaan, Raheem Khalid Abdul, O'Neil Tyriina K, Vanderby Ray, Demant Peter, Blank Robert D
Abstract excerpt
Despite steady progress in identifying quantitative trait loci (QTLs) for bone phenotypes, relatively little progress has been made in moving from QTLs to identifying the relevant gene. We exploited the genetic structure of recombinant congenic mouse strains by performing a reciprocal intercross of the strains HcB-8 and HcB-23, phenotyped for body size, femoral biomechanical performance, and femoral diaphyseal...
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