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Article

Quantitative trait loci affecting peak bone mineral density in mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 1998

Klein R F, Mitchell S R, Phillips T J, Belknap J K, Orwoll E S

Abstract excerpt

Peak bone mass is a major determinant of risk of osteoporotic fracture. Family and twin studies have found a strong genetic component to the determination of bone mineral density (BMD). However, BMD is a complex trait whose expression is confounded by environmental influences and polygenic inheritance. The number, locations, and effects of the individual genes contributing to natural variation in this trait are...

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PMID: 9797472
DOI: 10.1359/jbmr.1998.13.11.1648

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