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Article

A genome-wide association study in mice reveals a role for Rhbdf2 in skeletal homeostasis.

Scientific reports - 24 Feb 2020

Levy Roei, Levet Clemence, Cohen Keren, Freeman Matthew, Mott Richard, Iraqi Fuad, Gabet Yankel

Abstract excerpt

Low bone mass and an increased risk of fracture are predictors of osteoporosis. Individuals who share the same bone-mineral density (BMD) vary in their fracture risk, suggesting that microstructural architecture is an important determinant of skeletal strength. Here, we utilized the rich diversity of the Collaborative Cross mice to identify putative causal genes that contribute to the risk of fractures. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32094386
DOI: 10.1038/s41598-020-60146-8
PMCID: PMC7039944

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