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Article

A new HECT ubiquitin ligase regulating chemotaxis and development in Dictyostelium discoideum.

Journal of cell science - 1 Feb 2017

Pergolizzi Barbara, Bracco Enrico, Bozzaro Salvatore

Abstract excerpt

Cyclic AMP (cAMP) binding to G-protein-coupled receptors (GPCRs) orchestrates chemotaxis and development in Dictyostelium. By activating the RasC-TORC2-PKB (PKB is also known as AKT in mammals) module, cAMP regulates cell polarization during chemotaxis. TORC2 also mediates GPCR-dependent stimulation of adenylyl cyclase A (ACA), enhancing cAMP relay and developmental gene expression. Thus, mutants defective in the...

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Source

Identifiers

PMID: 28049717
DOI: 10.1242/jcs.194225

Genes

HERC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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