Article
Tumor necrosis factor alpha promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis.
Blood - 15 Jun 2001
Fargion S, Valenti L, Dongiovanni P, Scaccabarozzi A, Fracanzani A L, Taioli E, Mattioli M, Sampietro M, Fiorelli G
Abstract excerpt
Severe iron overload usually develops in patients with hereditary hemochromatosis (HHC), but variability in the phenotypic expression of the disease has been reported. This study assessed whether tumor necrosis factor alpha (TNF-alpha) plays a role in phenotypic expression of HHC. Sixty-four patients with HHC and 172 healthy volunteers (controls) were studied. Release of TNF-alpha from stimulated peripheral blood...
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